Publications

Publications

Comment & Editorial

display:none;
Muto V. & Berthomier C., Looking for a balance between visual and automatic sleep scoring, NPJ Digit Med. 2023

Muto V. & Berthomier C., Looking for a balance between visual and automatic sleep scoring, NPJ Digit Med. 2023 Sep 5;6(1):165. doi: 10.1038/s41746-023-00915-7. PMID: 37670135; PMCID: PMC10480143.

> Access the complete article Looking for a balance between visual and automatic sleep scoring.

Berthomier C. & Brandewinder M., EOG-based auto-staging: less is more, Sleep Breath, 2015

This issue of Sleep and Breathing presents the validation results of a new automated wake/sleep staging method based on EOG activity, developed by Jussi Virkkala from the Finnish Institute of Occupational Health. Classically, the automated method is compared to visual analysis, on an epoch by epoch basis. It reaches a level of global concordance of 88 % with a Kappa of 0.57. In other words, on the 248,696 epochs of the validation dataset, 212,138 were scored correctly in wake/sleep, that is as the human expert did it, and on 36,558 epochs, the two scorings differ.

> Full text: EOG-based auto-staging: less is more

Berthomier C. & Brandewinder M., Sleep scoring: man vs. machine ?, Sleep Breath., 2013

Berthomier C, Brandewinder M, Sleep scoring: man vs. machine ?, Sleep Breath. 17 (2):461-462, 2013

The automated analysis of sleep has grown in interest in the past decade. Advances in computing have brought the needed intensive calculations within reach; while simultaneously, there is an increasing demand for sleep diagnosis and analysis. The prevalence of sleep troubles is high, and the awareness of their consequences is spreading among patients, health authorities, and clinicians. This awareness is directing more and more patients to sleep centers. The upward trend in demand for sleep evaluations concerns not only sleep specialists. Sleep appears to be an extremely promising territory for other fields, such as cardiology and nutrition for example. Needs exceed capacities by this far. Data analysis has been identified as one of the bottlenecks in the sleep evaluation process, making clear the importance of developing tools to facilitate analysis. These developments have an impact that is medical, as well as economical and social.

> Full text: Sleep scoring: man vs. machine ?

Application

display:none;
Gobert F. et al., Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome. Commun Biol. 2023

Gobert F, Corneyllie A, Bastuji H, Berthomier C, Thevenet M, Abernot J, Raverot V, Dailler F, Guérin C, Gronfier C, Luauté J, Perrin F. Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome. Commun Biol. 2023 Nov 29;6(1):1213. doi: 10.1038/s42003-023-05588-2. PMID: 38030756; PMCID: PMC10687012.

 

> Texte complet Twenty-four-hour rhythmicities in disorders of consciousness are associated with a favourable outcome.

Deantoni M. et al., Napping and circadian sleep-wake regulation during healthy aging. Sleep. 2023

Deantoni M, Reyt M, Baillet M, Dourte M, De Haan S, Lesoinne A, Vandewalle G, Maquet P, Berthomier C, Muto V, Hammad G, Schmidt C. Napping and circadian sleep-wake regulation during healthy aging. Sleep. 2023 Nov 7:zsad287. doi: 10.1093/sleep/zsad287. Epub ahead of print. PMID: 37943833.

 

> Texte complet Napping and circadian sleep-wake regulation during healthy aging.

Deantoni M. et al., Association between circadian sleep regulation and cortical gyrification in young and older adults. Sleep. 2023

Deantoni M, Reyt M, Berthomier C, Muto V, Hammad G, De Haan S, Dourte M, Taillard J, Lambot E, Cajochen C, Reichert CF, Maire M, Baillet M, Schmidt C. Association between circadian sleep regulation and cortical gyrification in young and older adults. Sleep. 2023 Sep 8;46(9):zsad094. doi: 10.1093/sleep/zsad094. PMID: 37010079.

 

> Full text Association between circadian sleep regulation and cortical gyrification in young and older adults.

Koshmanova E. et al., Locus coeruleus activity while awake is associated with REM sleep quality in older individuals. JCI Insight. 2023

Koshmanova E, Berger A, Beckers E, Campbell I, Mortazavi N, Sharifpour R, Paparella I, Balda F, Berthomier C, Degueldre C, Salmon E, Lamalle L, Bastin C, Van Egroo M, Phillips C, Maquet P, Collette F, Muto V, Chylinski D, Jacobs HI, Talwar P, Sherif S, Vandewalle G. Locus coeruleus activity while awake is associated with REM sleep quality in older individuals. JCI Insight. 2023 Oct 23;8(20):e172008. doi: 10.1172/jci.insight.172008. PMID: 37698926; PMCID: PMC10619502.

 

> Full text Locus coeruleus activity while awake is associated with REM sleep quality in older individuals.

Deantoni M. et al., Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men. Neuroimage. 2023

Deantoni M, Baillet M, Hammad G, Berthomier C, Reyt M, Jaspar M, Meyer C, Van Egroo M, Talwar P, Lambot E, Chellappa SL, Degueldre C, Luxen A, Salmon E, Balteau E, Phillips C, Dijk DJ, Vandewalle G, Collette F, Maquet P, Muto V, Schmidt C. Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men. Neuroimage. 2023 May 15;272:120045. doi: 10.1016/j.neuroimage.2023.120045. Epub 2023 Mar 29. PMID: 36997136; PMCID: PMC10112274.

 

> Full text Association between sleep slow-wave activity and in-vivo estimates of myelin in healthy young men. 

 
André C. et al., Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging, Ann Neurol. 2023

André C, Champetier P, Rehel S, Kuhn E, Touron E, Ourry V, Landeau B, Le Du G, Mézenge F, Segobin S, de la Sayette V, Vivien D, Chételat G, Rauchs G; Medit-Ageing Research Group. Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging. Ann Neurol. 2023 May;93(5):979-990. doi: 10.1002/ana.26604. Epub 2023 Jan 27. PMID: 36641644.

 

> Full text Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging.

Koshmanova E. et al., Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers, Neurobiol Dis. 2022

Koshmanova E, Muto V, Chylinski D, Mouraux C, Reyt M, Grinard M, Talwar P, Lambot E, Berthomier C, Brandewinder M, Mortazavi N, Degueldre C, Luxen A, Salmon E, Georges M, Collette F, Maquet P, Van Someren E, Vandewalle G. Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers. Neurobiol Dis. 2022 Nov 9:105924. doi: 10.1016/j.nbd.2022.105924. Epub ahead of print. PMID: 36371058.

> Access the complete article Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers.

Duivon M. et al. Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task, Front Neurosci. 2022
Duivon M, Perrier J, Segura-Djezzar C, Joly F, Rehel S, Berthomier C, Grellard JM, Clarisse B, Geffrelot J, Emile G, Lévy C, Viader F, Eustache F, Desgranges B, Rauchs G, Giffard B. Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task. Front Neurosci. 2022 Sep 7;16:908268. doi: 10.3389/fnins.2022.908268. PMID: 36161169; PMCID: PMC9489900.
 

> Access the complete article Sleep-dependent memory consolidation in breast cancer: Use of a virtual reality prospective memory task.

 

Chylinski D. et al. Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife, Sleep 2022
Chylinski D, Narbutas J, Balteau E, Collette F, Bastin C, Berthomier C, Salmon E, Maquet P, Carrier J, Phillips C, Lina JM, Vandewalle G, Van Egroo M. Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife. Sleep. 2022 Jul 23:zsac178. doi: 10.1093/sleep/zsac178. Epub ahead of print. PMID: 35869626.
 

> Access the complete article Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife

 

Chylinski D. et al. Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline, Elife. 2022

Chylinski D, Van Egroo M, Narbutas J, Muto V, Bahri MA, Berthomier C, Salmon E, Bastin C, Phillips C, Collette F, Maquet P, Carrier J, Lina JM, Vandewalle G. Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline. Elife. 2022 May 31;11:e78191. doi: 10.7554/eLife.78191. PMID: 35638265..

> Access the complete article Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline

 

Berthomier C. & Brandewinder M., Analyse de l’électroencéphalogramme (EEG) de l’éveil et du sommeil chez l’homme–Monitoring EEG de gestion veille-sommeil, Médecine du sommeil, Elsevier, 2021

Analyse de l’électroencéphalogramme (EEG) de l’éveil et du sommeil chez l’homme–Monitoring EEG de gestion veille-sommeil, C Berthomier & M Brandewinder, Médecine du Sommeil, Elsevier, 2021

> Accéder à l’article Analyse de l’électroencéphalogramme (EEG) de l’éveil et du sommeil chez l’homme–Monitoring EEG de gestion veille-sommeil

Chylinski D. et al. Heterogeneity in the links between sleep arousals, amyloid-β, and cognition, JCI Insight 2021

Daphne O. Chylinski, Maxime Van Egroo, Justinas Narbutas, Martin Grignard, Ekaterina Koshmanova, Christian Berthomier, Pierre Berthomier, Marie Brandewinder, Eric Salmon, Mohamed Ali Bahri, Christine Bastin, Fabienne Collette, Christophe Phillips, Pierre Maquet, Vincenzo Muto, and Gilles Vandewalle. Heterogeneity in the links between sleep arousals, amyloid-β, and cognition. JCI Insight. 2021;6(24):e152858. https://doi.org/10.1172/jci.insight.152858.

> Access the complete article Heterogeneity in the links between sleep arousals, amyloid-β, and cognition

Weibel J. et al. Regular caffeine intake delays REM sleep promotion and attenuates sleep quality in healthy men, J Biol Rhythms 2021

Weibel J, Lin YS, Landolt HP, Berthomier C, Brandewinder M, Kistler J, Rehm S, Rentsch KM, Meyer M, Borgwardt S, Cajochen C, Reichert CF. Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men. J Biol Rhythms. 2021 May 23:7487304211013995. doi: 10.1177/07487304211013995. Epub ahead of print. PMID: 34024173.

 

Acute caffeine intake can attenuate homeostatic sleep pressure and worsen sleep quality. Caffeine intake-particularly in high doses and close to bedtime-may also affect circadian-regulated rapid eye movement (REM) sleep promotion, an important determinant of subjective sleep quality. However, it is not known whether such changes persist under chronic caffeine consumption during daytime.

Twenty male caffeine consumers (26.4 ± 4 years old, habitual caffeine intake 478.1 ± 102.8 mg/day) participated in a double-blind crossover study. Each volunteer completed a caffeine (3 × 150 mg caffeine daily for 10 days), a withdrawal (3 × 150 mg caffeine for 8 days then placebo), and a placebo condition. After 10 days of controlled intake and a fixed sleep-wake cycle, we recorded electroencephalography for 8 h starting 5 h after habitual bedtime (i.e., start on average at 04:22 h which is around the peak of circadian REM sleep promotion). A 60-min evening nap preceded each sleep episode and reduced high sleep pressure levels.

While total sleep time and sleep architecture did not significantly differ between the three conditions, REM sleep latency was longer after daily caffeine intake compared with both placebo and withdrawal. Moreover, the accumulation of REM sleep proportion was delayed, and volunteers reported more difficulties with awakening after sleep and feeling more tired upon wake-up in the caffeine condition compared with placebo. Our data indicate that besides acute intake, also regular daytime caffeine intake affects REM sleep regulation in men, such that it delays circadian REM sleep promotion when compared with placebo. Moreover, the observed caffeine-induced deterioration in the quality of awakening may suggest a potential motive to reinstate caffeine intake after sleep.

 

> Access the complete article Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men

Rousseau, P. F. et al., Sleep parameters improvement in PTSD soldiers after symptoms remission, Sc Rep. 2021

Sleep parameters improvement in PTSD soldiers after symptoms remission. Rousseau, P. F., Vallat, R., Coste, O., Cadis, H., Nicolas, F., Trousselard, M., Ruby P. & Khalfa, S. Scientific reports, 11(1), 1-13.

 

Eye movement desensitization and reprocessing (EMDR) is a psychotherapy for the treatment of posttraumatic stress disorder (PTSD). It is still unclear whether symptoms remission through EMDR therapy is associated with a beneficial effect on one of the PTSD symptoms, sleep disturbance.

Our objective was therefore to study sleep parameters before and after symptom remission in soldiers with PTSD.

The control group consisted of 20 healthy active duty military men who slept in a sleep lab with standard polysomnography (PSG) on two sessions separated by one month. The patient group consisted of 17 active duty military with PTSD who underwent EMDR therapy. PSG-recorded sleep was assessed 1week before the EMDR therapy began and 1week after PTSD remission.

We found that the increased REMs density after remission was positively correlated with a greater decrease of symptoms. Also, the number of EMDR sessions required to reach remission was correlated with intra-sleep awakenings before treatment.

These results confirm the improvement of some sleep parameters in PTSD after symptoms remission in a soldier’s population and provide a possible predictor of treatment success. Further experiments will be required to establish whether this effect is specific to the EMDR therapy.

 

> Access Sleep parameters improvement in PTSD soldiers after symptoms remission

Muto V. et al., Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness, Sleep 2021

Muto V, Koshmanova E, Ghaemmaghami P, Jaspar M, Meyer C, Elansary M, Van Egroo M, Chylinski D, Berthomier C, Brandewinder M, Mouraux C, Schmidt C, Hammad G, Coppieters W, Ahariz N, Degueldre C, Luxen A, Salmon E, Phillips C, Archer SN, Yengo L, Byrne E, Collette F, Georges M, Dijk DJ, Maquet P, Visscher PM, Vandewalle G. Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness. Sleep. 2021 Jan 21;44(1):zsaa137. doi: 10.1093/sleep/zsaa137. PMID: 32671396.

 

Study objectives: Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset.

Methods: We computed whole-genome PRS for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation, and extended sleep opportunity, in a carefully selected homogenous sample of 363 healthy young men (22.1 years ± 2.7) devoid of sleep and cognitive disorders.

Results: AD PRS was associated with more slow-wave energy, that is, the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with larger slow-wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness.

Conclusions: These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and support the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.

 

> Accéder à l’article Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness

Gaggioni G. et al., Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition, Neurobiology of Aging 2019

Giulia Gaggioni, Julien Q.M. Ly, Vincenzo Muto, Sarah L. Chellappa, Mathieu Jaspar, Christelle Meyer, Tillo Delfosse, Amaury Vanvinckenroye, Romain Dumont, Dorothée Coppieters ‘t Wallant, Christian Berthomier, Justinas Narbutas, Maxime Van Egroo, Andé Luxen, Eric Salmon, Fabienne Collette, Christophe Phillips, ChristinanSchmidt, Gilles Vandewalle, Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition, Neurobiology of Aging, Volume 78, June 2019

Cortical excitability depends on sleep-wake regulation, is central to cognition, and has been implicated in age-related cognitive decline. The dynamics of cortical excitability during prolonged wakefulness in aging are unknown, however. Here, we repeatedly probed cortical excitability of the frontal cortex using transcranial magnetic stimulation and electroencephalography in 13 young and 12 older healthy participants during sleep deprivation. Although overall cortical excitability did not differ between age groups, the magnitude of cortical excitability variations during prolonged wakefulness was dampened in older individuals. This age-related dampening was associated with mitigated neurobehavioral consequences of sleep loss on executive functions. Furthermore, higher cortical excitability was potentially associated with better and lower executive performance, respectively, in older and younger adults. The dampening of cortical excitability dynamics found in older participants likely arises from a reduced impact of sleep homeostasis and circadian processes. It may reflect reduced brain adaptability underlying reduced cognitive flexibility in aging. Future research should confirm preliminary associations between cortical excitability and behavior and address whether maintaining cortical excitability dynamics can counteract age-related cognitive decline.

> Access the complete article : Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition

Taillard J. et al., Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population, Front. Neurol. 2019

Jacques Taillard, Patricia Sagaspe, Christian Berthomier, Marie Brandewinder, Hélène Amieva, Jean-François Dartigues, Muriel Rainfray, Sandrine Harston, Jean-Arthur Micoulaud-Franchi and Pierre Philip, Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population, Front. Neurol., 13 March 2019 | https://doi.org/10.3389/fneur.2019.00197

Objective: Recent research suggests that sleep disorders or changes in sleep stages or EEG waveform precede over time the onset of the clinical signs of pathological cognitive impairment (e.g., Alzheimer’s disease). The aim of this study was to identify biomarkers based on EEG power values and spindle characteristics during sleep that occur in the early stages of mild cognitive impairment (MCI) in older adults.
Methods: This study was a case-control cross-sectional study with 1-year follow-up of cases. Patients with isolated subjective cognitive complaints (SCC) or MCI were recruited in the Bordeaux Memory Clinic (MEMENTO cohort). Cognitively normal controls were recruited. All participants were recorded with two successive polysomnography 1 year apart. Delta, theta, and sigma absolute spectral power and spindle characteristics (frequency, density, and amplitude) were analyzed from purified EEG during NREM and REM sleep periods during the entire second night.
Results: Twenty-nine patients (8 males, age = 71 ± 7 years) and 29 controls were recruited at T0. Logistic regression analyses demonstrated that age-related cognitive impairment were associated with a reduced delta power (odds ratio (OR) 0.072, P < 0.05), theta power (OR 0.018, P < 0.01), sigma power (OR 0.033, P < 0.05), and spindle maximal amplitude (OR 0.002, P < 0.05) during NREM sleep. Variables were adjusted on age, gender, body mass index, educational level, and medication use. Seventeen patients were evaluated at 1-year follow-up. Correlations showed that changes in self-reported sleep complaints, sleep consolidation, and spindle characteristics (spectral power, maximal amplitude, duration, and frequency) were associated with cognitive impairment (P < 0.05).
Conclusion: A reduction in slow-wave, theta and sigma activities, and a modification in spindle characteristics during NREM sleep are associated very early with a greater risk of the occurrence of cognitive impairment. Poor sleep consolidation, lower amplitude, and faster frequency of spindles may be early sleep biomarkers of worsening cognitive decline in older adults.

> Full text: Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population

Maire M., et al. Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement, Sci Rep. 2018

Maire M, Reichert CF, Gabel V, Viola AU, Phillips C, Berthomier C, Borgwardt S, Cajochen C, Schmidt C. Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement. Sci Rep. 2018 Jan 17;8(1):970. doi: 10.1038/s41598-017-17022-9. Sleepiness and cognitive function vary over the 24-h day due to circadian and sleep-wake-dependent mechanisms. However, the underlying cerebral hallmarks associated with these variations remain to be fully established. Using functional magnetic resonance imaging (fMRI), we investigated brain responses associated with circadian and homeostatic sleep-wake-driven dynamics of subjective sleepiness throughout day and night. Healthy volunteers regularly performed a psychomotor vigilance task (PVT) in the MR-scanner during a 40-h sleep deprivation (high sleep pressure) and a 40-h multiple nap protocol (low sleep pressure). When sleep deprived, arousal-promoting thalamic activation during optimal PVT performance paralleled the time course of subjective sleepiness with peaks at night and troughs on the subsequent day. Conversely, task-related cortical activation decreased when sleepiness increased as a consequence of higher sleep debt. Under low sleep pressure, we did not observe any significant temporal association between PVT-related brain activation and subjective sleepiness. Thus, a circadian modulation in brain correlates of vigilant attention was only detectable under high sleep pressure conditions. Our data indicate that circadian and sleep homeostatic processes impact on vigilant attention via specific mechanisms; mirrored in a decline of cortical resources under high sleep pressure, opposed by a subcortical « rescuing » at adverse circadian times. > Full text: Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement

Dang-Vu T. T., et al., Sleep spindles may predict response to cognitive behavioral therapy for chronic insomnia, Sleep Med., 2017

Dang-Vu TT, Hatch B, Salimi A, Mograss M, Boucetta S, O’Byrne J, Brandewinder M, Berthomier C, Gouin JP., Sleep spindles may predict response to cognitive behavioral therapy for chronic insomnia, Sleep Med. 2017 Nov;39:54-61. doi: 10.1016/j.sleep.2017.08.012. BACKGROUND: While cognitive-behavioral therapy for insomnia constitutes the first-line treatment for chronic insomnia, only few reports have investigated how sleep architecture relates to response to this treatment. In this pilot study, we aimed to determine whether pre-treatment sleep spindle density predicts treatment response to cognitive-behavioral therapy for insomnia. METHODS: Twenty-four participants with chronic primary insomnia participated in a 6-week cognitive-behavioral therapy for insomnia performed in groups of 4-6 participants. Treatment response was assessed using the Pittsburgh Sleep Quality Index and the Insomnia Severity Index measured at pre- and post-treatment, and at 3- and 12-months’ follow-up assessments. Secondary outcome measures were extracted from sleep diaries over 7 days and overnight polysomnography, obtained at pre- and post-treatment. Spindle density during stage N2-N3 sleep was extracted from polysomnography at pre-treatment. Hierarchical linear modeling analysis assessed whether sleep spindle density predicted response to cognitive-behavioral therapy. RESULTS: After adjusting for age, sex, and education level, lower spindle density at pre-treatment predicted poorer response over the 12-month follow-up, as reflected by a smaller reduction in Pittsburgh Sleep Quality Index over time. Reduced spindle density also predicted lower improvements in sleep diary sleep efficiency and wake after sleep onset immediately after treatment. There were no significant associations between spindle density and changes in the Insomnia Severity Index or polysomnography variables over time. CONCLUSION: These preliminary results suggest that inter-individual differences in sleep spindle density in insomnia may represent an endogenous biomarker predicting responsiveness to cognitive-behavioral therapy. Insomnia with altered spindle activity might constitute an insomnia subtype characterized by a neurophysiological vulnerability to sleep disruption associated with impaired responsiveness to cognitive-behavioral therapy. > Abstract: Sleep spindles may predict response to cognitive-behavioral therapy for chronic insomnia.

Reichert C.F., et al., Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations, Sci Rep. 2017

Reichert CF, Maire M, Gabel V, Viola AU, Götz T, Scheffler K, Klarhöfer M, Berthomier C, Strobel W, Phillips C, Salmon E, Cajochen C, Schmidt C., Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations, Sci Rep. 2017 Jul 17;7(1):5620. doi: 10.1038/s41598-017-05695-1. The two-process model of sleep-wake regulation posits that sleep-wake-dependent homeostatic processes interact with the circadian timing system to affect human behavior. The circadian timing system is fundamental to maintaining stable cognitive performance, as it counteracts growing homeostatic sleep pressure during daytime. Using magnetic resonance imaging, we explored brain responses underlying working memory performance during the time of maximal circadian wake-promotion under varying sleep pressure conditions. Circadian wake-promoting strength was derived from the ability to sleep during an evening nap. Hypothalamic BOLD activity was positively linked to circadian wake-promoting strength under normal, but not under disproportionally high or low sleep pressure levels. Furthermore, higher hypothalamic activity under normal sleep pressure levels predicted better performance under sleep loss. Our results reappraise the two-process model by revealing a homeostatic-dose-dependent association between circadian wake-promotion and cognition-related hypothalamic activity. > Full text: Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations

Vallat R., et al., Increased Evoked Potentials to Arousing Auditory Stimuli during Sleep: Implication for the Understanding of Dream Recall, Front Hum Neurosci. 2017

Vallat R, Lajnef T, Eichenlaub JB, Berthomier C, Jerbi K, Morlet D, Ruby PM., Increased Evoked Potentials to Arousing Auditory Stimuli during Sleep: Implication for the Understanding of Dream Recall. Front Hum Neurosci. 2017 Mar 21;11:132. doi: 10.3389/fnhum.2017.00132. eCollection 2017. High dream recallers (HR) show a larger brain reactivity to auditory stimuli during wakefulness and sleep as compared to low dream recallers (LR) and also more intra-sleep wakefulness (ISW), but no other modification of the sleep macrostructure. To further understand the possible causal link between brain responses, ISW and dream recall, we investigated the sleep microstructure of HR and LR, and tested whether the amplitude of auditory evoked potentials (AEPs) was predictive of arousing reactions during sleep. Participants (18 HR, 18 LR) were presented with sounds during a whole night of sleep in the lab and polysomnographic data were recorded. Sleep microstructure (arousals, rapid eye movements (REMs), muscle twitches (MTs), spindles, KCs) was assessed using visual, semi-automatic and automatic validated methods. AEPs to arousing (awakenings or arousals) and non-arousing stimuli were subsequently computed. No between-group difference in the microstructure of sleep was found. In N2 sleep, auditory arousing stimuli elicited a larger parieto-occipital positivity and an increased late frontal negativity as compared to non-arousing stimuli. As compared to LR, HR showed more arousing stimuli and more long awakenings, regardless of the sleep stage but did not show more numerous or longer arousals. These results suggest that the amplitude of the brain response to stimuli during sleep determine subsequent awakening and that awakening duration (and not arousal) is the critical parameter for dream recall. Notably, our results led us to propose that the minimum necessary duration of an awakening during sleep for a successful encoding of dreams into long-term memory is approximately 2 min. > Full text: Increased Evoked Potentials to Arousing Auditory Stimuli during Sleep: Implication for the Understanding of Dream

Dang-Vu T. T., et al., Sleep spindles predict stress-related increases in sleep disturbances, Front. Hum. Neurosci., 2015

Dang-Vu T. T., Salimi A., Boucetta S., Wenzel K., O’Byrne J., M. Brandewinder M., Berthomier C. and Gouin J.-P.. Sleep spindles predict stress-related increases in sleep disturbances. Front. Hum. Neurosci., 10 February 2015 | doi: 10.3389/fnhum.2015.00068 The aim of this study was to prospectively assess whether spindle density would predict the worsening of sleep disturbances in response to a standardized stressor. We chose to follow a population of undergraduate university students during a period of increasing academic stress. In this context, assessing students at the beginning of the semester, corresponding to a lower stress period, and reevaluating them during a follow-up in the week preceding the final examinations, a period of higher stress, provides a unique opportunity to examine individual differences in the evolution of insomnia symptoms in response to a standardized stressor. > Full text: Sleep spindles predict stress-related increases in sleep disturbances

Eichenlaub JB, et al., Brain Reactivity Differentiates Subjects with High and Low Dream Recall Frequencies during Both Sleep and Wakefulness, Cereb. Cortex 2014
Eichenlaub JB, Bertrand O, Morlet D, Ruby P. Brain Reactivity Differentiates Subjects with High and Low Dream Recall Frequencies during Both Sleep and Wakefulness. Cereb. Cortex 24 (5): 1206-1215. 2014
 
The neurophysiological correlates of dreaming remain unclear. According to the « arousal-retrieval » model, dream encoding depends on intrasleep wakefulness. Consistent with this model, subjects with high and low dream recall frequency (DRF) report differences in intrasleep awakenings. This suggests a possible neurophysiological trait difference between the 2 groups. To test this hypothesis, we compared the brain reactivity (evoked potentials) of subjects with high (HR, N = 18) and low (LR, N = 18) DRF during wakefulness and sleep. During data acquisition, the subjects were presented with sounds to be ignored (first names randomly presented among pure tones) while they were watching a silent movie or sleeping. Brain responses to first names dramatically differed between the 2 groups during both sleep and wakefulness. During wakefulness, the attention-orienting brain response (P3a) and a late parietal response were larger in HR than in LR. During sleep, we also observed between-group differences at the latency of the P3a during N2 and at later latencies during all sleep stages. Our results demonstrate differences in the brain reactivity of HR and LR during both sleep and wakefulness. These results suggest that the ability to recall dreaming is associated with a particular cerebral functional organization, regardless of the state of vigilance.
 
Ruby P, et al., Alpha Reactivity to Complex Sounds Differs during REM Sleep and Wakefulness, PLoS ONE 2013

Ruby P, Blochet C, Eichenlaub J-B, Bertrand O, Morlet D, Bidet-Caulet A. Alpha Reactivity to Complex Sounds Differs during REM Sleep and Wakefulness. PLoS ONE 8(11): e79989, 2013.

We aimed at better understanding the brain mechanisms involved in the processing of alerting meaningful sounds during sleep, investigating alpha activity. During EEG acquisition, subjects were presented with a passive auditory oddball paradigm including rare complex sounds called Novels (the own first name – OWN, and an unfamiliar first name – OTHER) while they were watching a silent movie in the evening or sleeping at night. During the experimental night, the subjects’ quality of sleep was generally preserved. During wakefulness, the decrease in alpha power (8–12 Hz) induced by Novels was significantly larger for OWN than for OTHER at parietal electrodes, between 600 and 900 ms after stimulus onset. Conversely, during REM sleep, Novels induced an increase in alpha power (from 0 to 1200 ms at all electrodes), significantly larger for OWN than for OTHER at several parietal electrodes between 700 and 1200 ms after stimulus onset. These results show that complex sounds have a different effect on the alpha power during wakefulness (decrease) and during REM sleep (increase) and that OWN induce a specific effect in these two states. The increased alpha power induced by Novels during REM sleep may 1) correspond to a short and transient increase in arousal; in this case, our study provides an objective measure of the greater arousing power of OWN over OTHER, 2) indicate a cortical inhibition associated with sleep protection. These results suggest that alpha modulation could participate in the selection of stimuli to be further processed during sleep.

> Full text Alpha Reactivity to Complex Sounds Differs during REM Sleep and Wakefulness

Ruby P, et al., Alpha reactivity to first names differs in subjects with high and low dream recall frequency, Front Psychol 2013

Ruby P, Blochet C, Eichenlaub JB, Bertrand O, Morlet D, Bidet-Caulet A. Alpha reactivity to first names differs in subjects with high and low dream recall frequency. Front Psychol.;4:419, 2013.

Studies in cognitive psychology showed that personality (openness to experience, thin boundaries, absorption), creativity, nocturnal awakenings, and attitude toward dreams are significantly related to dream recall frequency (DRF). These results suggest the possibility of neurophysiological trait differences between subjects with high and low DRF. To test this hypothesis we compared sleep characteristics and alpha reactivity to sounds in subjects with high and low DRF using polysomnographic recordings and electroencephalography (EEG). We acquired EEG from 21 channels in 36 healthy subjects while they were presented with a passive auditory oddball paradigm (frequent standard tones, rare deviant tones and very rare first names) during wakefulness and sleep (intensity, 50 dB above the subject’s hearing level). Subjects were selected as High-recallers (HR, DRF = 4.42 ± 0.25 SEM, dream recalls per week) and Low-recallers (LR, DRF = 0.25 ± 0.02) using a questionnaire and an interview on sleep and dream habits. Despite the disturbing setup, the subjects’ quality of sleep was generally preserved. First names induced a more sustained decrease in alpha activity in HR than in LR at Pz (1000–1200 ms) during wakefulness, but no group difference was found in REM sleep. The current dominant hypothesis proposes that alpha rhythms would be involved in the active inhibition of the brain regions not involved in the ongoing brain operation. According to this hypothesis, a more sustained alpha decrease in HR would reflect a longer release of inhibition, suggesting a deeper processing of complex sounds than in LR during wakefulness. A possibility to explain the absence of group difference during sleep is that increase in alpha power in HR may have resulted in awakenings. Our results support this hypothesis since HR experienced more intra sleep wakefulness than LR (30 ± 4 vs. 14 ± 4 min). As a whole our results support the hypothesis of neurophysiological trait differences in high and low-recallers.

> Full text: Alpha reactivity to first names differs in subjects with high and low dream recall frequency

Schmidt C, et al., Circadian preference modulates the neural substrate of conflict processing across the day, PLoS One 2012

Schmidt C, Peigneux P, Leclercq Y, Sterpenich V, Vandewalle G, Philips C, Berthomier P, Berthomier C, Tinguely G, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Degueldre C, Balteau E, Luxen A, Cajochen C, Maquet P, Collette F. Circadian preference modulates the neural substrate of conflict processing across the day. PLoS One. 2012;7(1):e29658. 2012 Jan 4. PLoS One. 2012;7(1):e29658. 2012 Jan 4.

Human morning and evening chronotypes differ in their preferred timing for sleep and wakefulness, as well as in optimal daytime periods to cope with cognitive challenges. Recent evidence suggests that these preferences are not a simple by-product of socio-professional timing constraints, but can be driven by inter-individual differences in the expression of circadian and homeostatic sleep-wake promoting signals. Chronotypes thus constitute a unique tool to access the interplay between those processes under normally entrained day-night conditions, and to investigate how they impinge onto higher cognitive control processes. Using functional magnetic resonance imaging (fMRI), we assessed the influence of chronotype and time-of-day on conflict processing-related cerebral activity throughout a normal waking day. Sixteen morning and 15 evening types were recorded at two individually adapted time points (1.5 versus 10.5 hours spent awake) while performing the Stroop paradigm. Results show that interference-related hemodynamic responses are maintained or even increased in evening types from the subjective morning to the subjective evening in a set of brain areas playing a pivotal role in successful inhibitory functioning, whereas they decreased in morning types under the same conditions. Furthermore, during the evening hours, activity in a posterior hypothalamic region putatively involved in sleep-wake regulation correlated in a chronotype-specific manner with slow wave activity at the beginning of the night, an index of accumulated homeostatic sleep pressure. These results shed light into the cerebral mechanisms underlying inter-individual differences of higher-order cognitive state maintenance under normally entrained day-night conditions.

> Full text: Circadian preference modulates the neural substrate of conflict processing across the day

Schmidt C, et al., Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area, Science 2009

Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, Berthomier P, Berthomier C, Philipps C, Tinguely G, Darsaud A, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Balteau E, Degueldre C, Luxen A, Maquet P, Cajochen C, Peigneux P, Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area, Science, 324 (5926):516-9, 2009.

Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.

> Abstract: Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area

Validation and R&D

display:none;
Tankéré P. et al., Revisiting the maintenance of wakefulness test: from intra-/inter-scorer agreement to normative values in patients treated for obstructive sleep apnea, J Sleep Res. 2023

Tankéré P, Taillard J, Armeni MA, Petitjean T, Berthomier C, Strauss M, Peter-Derex L. Revisiting the maintenance of wakefulness test: from intra-/inter-scorer agreement to normative values in patients treated for obstructive sleep apnea. J Sleep Res. 2023 Jun 7:e13961. doi: 10.1111/jsr.13961. Epub ahead of print. PMID: 37287324.

 

> Full text Revisiting the maintenance of wakefulness test: from intra-/inter-scorer agreement to normative values in patients treated for obstructive sleep apnea

Chylinski D. et al., Variability of sleep stage scoring in late midlife and early old age, J Sleep Res. 2021

Variability of sleep stage scoring in late midlife and early old age, Chylinski D., Berthomier C., Lambot E., Frenette S., Brandewinder M., Carrier J., Vandewalle G. & Muto V. J Sleep Res. 2021 Jun 24:e13424. doi: 10.1111/jsr.13424. Epub ahead of print. PMID: 34169604.

 

Study objectives: To assess the performance of the single-channel automatic sleep staging (AS) software ASEEGA in adult patients diagnosed with various sleep disorders.

Methods: Sleep recordings were included of 95 patients (38 women, 40.5 ± 13.7 years) diagnosed with insomnia (n = 23), idiopathic hypersomnia (n = 24), narcolepsy (n = 24), and obstructive sleep apnea (n = 24). Visual staging (VS) was performed by two experts (VS1 and VS2) according to the American Academy of Sleep Medicine rules. AS was based on the analysis of a single electroencephalogram channel (Cz-Pz), without any information from electro-oculography nor electromyography. The epoch-by-epoch agreement (concordance and Conger’s coefficient [κ]) was compared pairwise (VS1-VS2, AS-VS1, AS-VS2) and between AS and consensual VS. Sleep parameters were also compared.

Results: The pairwise agreements were: between AS and VS1, 78.6% (κ = 0.70); AS and VS2, 75.0% (0.65); and VS1 and VS2, 79.5% (0.72). Agreement between AS and consensual VS was 85.6% (0.80), with the following distribution: insomnia 85.5% (0.80), narcolepsy 83.8% (0.78), idiopathic hypersomnia 86.1% (0.68), and obstructive sleep disorder 87.2% (0.82). A significant low-amplitude scorer effect was observed for most sleep parameters, not always driven by the same scorer. Hypnograms obtained with AS and VS exhibited very close sleep organization, except for 80% of rapid eye movement sleep onset in the group diagnosed with narcolepsy missed by AS.

Conclusions: Agreement between AS and VS in sleep disorders is comparable to that reported in healthy individuals and to interexpert agreement in patients. ASEEGA could therefore be considered as a complementary sleep stage scoring tool in clinical practice, after improvement of rapid eye movement sleep onset detection.

 

> Access Variability of sleep stage scoring in late midlife and early old age

Peter-Derex L. et al., Automatic analysis of single-channel sleep EEG in a large spectrum of sleep disorders, J of Clin Sleep Med. 2021

Automatic analysis of single-channel sleep EEG in a large spectrum of sleep disorders. Journal of Clinical Sleep Medicine 2021; 17 (3), 393-402, Peter-Derex L, Berthomier C, Taillard J, Berthomier P, Bouet R, Mattout J, Brandewinder M, Bastuji H. 

Study objectives: To assess the performance of the single-channel automatic sleep staging (AS) software ASEEGA in adult patients diagnosed with various sleep disorders.

Methods: Sleep recordings were included of 95 patients (38 women, 40.5 ± 13.7 years) diagnosed with insomnia (n = 23), idiopathic hypersomnia (n = 24), narcolepsy (n = 24), and obstructive sleep apnea (n = 24). Visual staging (VS) was performed by two experts (VS1 and VS2) according to the American Academy of Sleep Medicine rules. AS was based on the analysis of a single electroencephalogram channel (Cz-Pz), without any information from electro-oculography nor electromyography. The epoch-by-epoch agreement (concordance and Conger’s coefficient [κ]) was compared pairwise (VS1-VS2, AS-VS1, AS-VS2) and between AS and consensual VS. Sleep parameters were also compared.

Results: The pairwise agreements were: between AS and VS1, 78.6% (κ = 0.70); AS and VS2, 75.0% (0.65); and VS1 and VS2, 79.5% (0.72). Agreement between AS and consensual VS was 85.6% (0.80), with the following distribution: insomnia 85.5% (0.80), narcolepsy 83.8% (0.78), idiopathic hypersomnia 86.1% (0.68), and obstructive sleep disorder 87.2% (0.82). A significant low-amplitude scorer effect was observed for most sleep parameters, not always driven by the same scorer. Hypnograms obtained with AS and VS exhibited very close sleep organization, except for 80% of rapid eye movement sleep onset in the group diagnosed with narcolepsy missed by AS.

Conclusions: Agreement between AS and VS in sleep disorders is comparable to that reported in healthy individuals and to interexpert agreement in patients. ASEEGA could therefore be considered as a complementary sleep stage scoring tool in clinical practice, after improvement of rapid eye movement sleep onset detection.

> Access the abstract Automatic analysis of single-channel sleep EEG in a large spectrum of sleep disorders

Berthomier C. et al., Automatic Analysis of Single-Channel Sleep EEG: Validation in Healthy Individuals, Sleep, 2007

Berthomier C; Drouot X; Herman-Stoïca M; Berthomier P; Prado J; Bokar-Thire D; Benoit O; Mattout J; d’Ortho MP., Automatic Analysis of Single-Channel Sleep EEG: Validation in Healthy Individuals, Sleep 2007;30(11):1587-1595.

STUDY OBJECTIVE: To assess the performance of automatic sleep scoring software (ASEEGA) based on a single EEG channel comparatively with manual scoring (2 experts) of conventional full polysomnograms.

DESIGN: Polysomnograms from 15 healthy individuals were scored by 2 independent experts using conventional R&K rules. The results were compared to those of ASEEGA scoring on an epoch-by-epoch basis.

SETTING: Sleep laboratory in the physiology department of a teaching hospital.

PARTICIPANTS: Fifteen healthy volunteers.

MEASUREMENTS AND RESULTS: The epoch-by-epoch comparison was based on classifying into 2 states (wake/sleep), 3 states (wake/REM/ NREM), 4 states (wake/REM/stages 1-2/SWS), or 5 states (wake/REM/ stage 1/stage 2/SWS). The obtained overall agreements, as quantified by the kappa coefficient, were 0.82, 0.81, 0.75, and 0.72, respectively. Furthermore, obtained agreements between ASEEGA and the expert consensual scoring were 96.0%, 92.1%, 84.9%, and 82.9%, respectively. Finally, when classifying into 5 states, the sensitivity and positive predictive value of ASEEGA regarding wakefulness were 82.5% and 89.7%, respectively. Similarly, sensitivity and positive predictive value regarding REM state were 83.0% and 89.1%.

CONCLUSIONS: Our results establish the face validity and convergent validity of ASEEGA for single-channel sleep analysis in healthy individuals. ASEEGA appears as a good candidate for diagnostic aid and automatic ambulant scoring.

> Full text: Automatic Analysis of Single-Channel Sleep EEG: Validation in Healthy Individuals

Berthomier C. et al., Real-Time Automatic Measurement of Recorded Sleep Time, Chest 2007
Berthomier C, Berthomier P, Herman-Stoïca M, Drouot X, Prado J, Benoit O, Mattout J, d’Ortho MP, Real-Time Automatic Measurement of Recorded Sleep Time, Chest, 132/4 (Suppl.) 649S, 2007 American College of Chest Physicians (ACCP) congress: CHEST. 20-25 octobre 2007, Chicago, Il, USA

Conferences

display:none;
Mortazavi N., et al., Association of Alzheimer’s disease genetic risk and EEG features of the awake brain in healthy young men, ESRS 2022

Association of Alzheimer’s disease genetic risk and EEG features of the awake brain in healthy young men, N Mortazavi, E Koshmanova, V Muto, D Chylinski, M Jaspar, C Meyer, R Sharifpour, A Berger, I Paparella, I Campbell, E Beckers, C Degueldre, C Berthomier, C Schmidt, F Collette, D Dijk, C Phillips, P Maquet, P Talwar, G Vandewalle

26th Conference of the European Sleep Research Society (ESRS 2022)

Koshmanova E., et al., Locus coeruleus reactivity during wakefulness is associated with REM sleep intensity, ESRS 2022

Locus coeruleus reactivity during wakefulness is associated with REM sleep intensity, E Koshmanova, A Berger, N Mortazavi, E Beckers, J Ji, I Campbell, R Sharifpour, I Paparella, D Chylinski, V Muto,

26th Conference of the European Sleep Research Society (ESRS 2022)

Mortazavi N., et al., Alzheimer’s disease genetic risk and electroencephalography signals during wakefulness: Insights into the possible disease correlation, ESRS 2022

Alzheimer’s disease genetic risk and electroencephalography signals during wakefulness: Insights into the possible disease correlation, N Mortazavi, E Koshmanova, V Muto, D Chylinski, M Jaspar, C Meyer, R Sharifpour, A Berger, I Paparella, I Campbell, E Beckers, C Degueldre, C Berthomier, C Schmidt, F Collette, DJ Dijk, C Phillips, P Maquet, P Talwar, G Vandewalle

The 26th Conference of the European Sleep Research Society (ESRS 2022)

de Haan S., et al., Modelling age-related changes in human sleep across the 24h-cycle: impact of circadian amplitude and wake-promoting inputs to the monoaminergic system, 2022

Modelling age-related changes in human sleep across the 24h-cycle: impact of circadian amplitude and wake-promoting inputs to the monoaminergic system, S de Haan, M Baillet, M Deantoni, M Reyt, M Dourte, V Muto, C Phillips, C Phillips, P Maquet, C Berthomier, S Postnova, C Schmidt, G Hammad

Sleep Europe 2022

Chylinski D., et al., Spindle-slow wave coupling is linked to early amyloid-β burden and predicts memory decline, Gordon Conference, 2022

Spindle-slow wave coupling is linked to early amyloid-β burden and predicts memory decline, D Chylinski, M Van Egroo, J Narbutas, V Muto, MA Bahri, C Berthomier, M Brandewinder,, E Salmon, C Bastin, C Phillips

Gordon conference on Sleep Function, 2022

Chylinski D., et al., Timely sleep coupling: phase locked slow wave-spindle pairing is linked to AD neuropathology and forecasts cognitive decline, 2021

Timely sleep coupling: phase locked slow wave-spindle pairing is linked to AD neuropathology and forecasts cognitive decline, D Chylinski, M Van Egroo, J Narbutas, C Berthomier, M Brandewinder, E Salmon, MA Bahri, V Muto, C Bastin, F Collette

Belgian Association for Sleep research and Sleep medicine, 2021

Peter-Derex L., et al., Sleep autoscoring based on a single EEG channel: comparison with visual scoring in patients, Sleep Medicine 2019

Sleep autoscoring based on a single EEG channel: comparison with visual scoring in patients, L. Peter-Derex, C. Berthomier, J. Taillard, P. Berthomier, J. Mattout, M. Brandewinder, H. Bastuji, Sleep Medicine, Volume 64, Supplement 1, December 2019, Page S34

> Access the article Sleep autoscoring based on a single EEG channel: comparison with visual scoring in patients

Chylinski D., et al., Sleep fragmentation is associated with brain tau but not amyloid-β burden in healthy older adults, Front. Neurosci. Conference Abstract 2019

Chylinski D, Rudzik F, Coppieters ‘T Wallant D, Van Egroo M, Muto V, Narbutas J, Villar González P, Besson G, Lambot E, Laloux S, Hagelstein C, Ghaemmaghami P, Degueldre C, Berthomier C, Bethomier P, Brandewinder M, Schmidt C, Maquet P, Salmon E, Phillips C, Bahri M, Bastin C, Collette F and Vandewalle G (2019). Sleep fragmentation is associated with brain tau but not amyloid-β burden in healthy older adults. Front. Neurosci. Conference Abstract: Belgian Brain Congress 2018 —

Belgian Brain Council. doi: 10.3389/conf.fnins.2018.95.00054

Belgian Brain Congress 2018

Taillard J. et al., Guidelines for the application of the Objective Sleepiness Scale for drowsiness assessment, 2019

Guidelines for the application of the Objective Sleepiness Scale for drowsiness assessment , Taillard J., Brandewinder M., Berthomier P., Berthomier C.

ESRS Basel, Swizterland
20-25 September 2019

Chylinski D. et al., Arousals during sleep are associated with brain tau and amyloid-β burden in healthy older adults, 2018

Arousals during sleep are associated with brain tau and amyloid-β burden in healthy older adults, D Chylinski, F Rudzik, C Wallant, M Van Egroo, V Muto, J Narbutas, P Villar Gonzalez, G Besson, E Lambot, S Laloux, C Hagelstein, P Ghaemmaghami Tabrizi, C Degueldre, C Berthomier, P Berthomier, M Brandewinder, C Schmidt, P Maquet, E Salmon, C Phillips, MA Bahri, C Bastin, F Collette, G Vandewalle

ESRS Basel, Swizterland
20-25 September 2018

Ghaemmaghami P. et al., Predicted gene expression in the brain is associated with sleep macrostructure in healthy young individuals, 2018

Predicted gene expression in the brain is associated with sleep macrostructure in healthy young individuals, P Ghaemmaghami, V Muto, M Jaspar, C Meyer, M Elansary, M Van Egroo, C Berthomier, E Lambot, J Devillers, M Brandewinder, A Luxen, C Degueldre, E Salmon, F Collette, SN Archer, C Phillips, D-J Dijk, M Georges, P Maquet, G Vandewalle

ESRS Basel, Swizterland
20-25 September 2018

Ghaemmaghami P. et al., Volume of subcortical brain areas is associated with sleep macrostructure in healthy young individuals, 2018

Volume of subcortical brain areas is associated with sleep macrostructure in healthy young individuals, P Ghaemmaghami, V Muto, M Jaspar, C Meyer, M Elansary, M Van Egroo, C Berthomier, E Lambot, M Brandewinder, A Luxen, C Degueldre, E Salmon, S Archer, C Phillips, D-J Dijk, M Georges, P Maquet, G Vandewalle

ESRS Basel, Swizterland
20-25 September 2018

Ghaemmaghami P. et al., Predicted gene expression in the brain is associated with sleep macrostructure in healthy young individuals, 2018

Predicted gene expression in the brain is associated with sleep macrostructure in healthy young individuals, P Ghaemmaghami, V Muto, M Jaspar, C Meyer, M Elansary, M Van Egroo, C Berthomier, E Lambot, J Devillers, M Brandewinder, A Luxen, C Degueldre, E Salmon, F Collette, SN Archer, C Phillips, D-J Dijk, M Georges, P Maquet, G Vandewalle

ESRS Basel, Swizterland
20-25 September 2018

Ghaemmaghami P. et al., The genetic liability for insomnia is associated with the number of awakenings during sleep in young and healthy individuals, 2018

The genetic liability for insomnia is associated with the number of awakenings during sleep in young and healthy individuals, Ghaemmaghami, P., Muto, V., Jaspar, M., Meyer, C., Elansary, M., Van Egroo, M., Berthomier, C., Lambot, E., Brandewinder, M., Luxen, A., Degueldre, C., Salmon, E., Archer, S., Phillips, C., Dijk, D. -J., Visscher, P., Posthuma, D., Van Someren, E., Collette, F., Georges, M., Maquet, P., Vandewalle, G.

ESRS Basel, Swizterland
20-25 September 2018

Escourrou P. J., et al., Respiratory events during stable wake in sleep apnea patients: occurrence and mechanism, European Respiratory Journal 2018

P. J. Escourrou, M. Brandewinder, C. Berthomier, P. Berthomier, G. Baffet, Z. Balekji, N. Puisais, G. Roisman, Respiratory events during stable wake in sleep apnea patients: occurrence and mechanism., European Respiratory Journal 2018 52: PA2509; DOI: 10.1183/13993003.congress-2018.PA2509

Berthomier C. et al., MEEGAWAKE Guidelines for Drowsiness Assessment using Objective Sleepiness Score, 2018

Berthomier C., Brandewinder M., Mattout J., Taillard J., MEEGAWAKE Guidelines for Drowsiness Assessment using Objective Sleepiness Score.

SIDs Salzburg 2018

Taillard J. et al., Lower delta, theta and sigma EEG power are associated with cognitive impairment in an aging population, 2016

Taillard J., Sagaspe P., Berthomier C., Brandewinder M., Amiéva H., Dartigues JF., Rainfray M., Harston S., Philip P, Lower delta, theta and sigma EEG power are associated with cognitive impairment in an aging population.

ESRS Bologna 2016

O'Byrne J, et al., Spindles and slow waves predict treatment responses to cognitive-behavioural therapy for chronic primary insomnia, J. Sleep Res. 2014

O’Byrne J, Boucetta S, Reed L,Malhi O, Zhang V, Arcelin A, Wenzel K, Brandewinder M, Berthomier C, Gouin J-P, Dang-Vu TT. Spindles and slow waves predict treatment responses to cognitive-behavioural therapy for chronic primary insomnia. J. Sleep Res., 23 Suppl. 1:209, 2014

22nd ESRS Congress, Tallinn, Estonia
16 – 20 September 2014

Sagaspe P, et al., Polysomnographic data in patients with isolated memory complaints or mild cognitive impairment, J. Sleep Res. 2014

Sagaspe P, Taillard J, Chaufton C, Berthomier C, Brandewinder M, Amiéva H, Dartigues J-F, Philip P. Polysomnographic data in patients with isolated memory complaints or mild cognitive impairment. J. Sleep Res., 23 Suppl. 1:240, 2014

22nd ESRS Congress, Tallinn, Estonia
16 – 20 September 2014

Schmidt C, et al., Circadian and homeostatic modulation of cognition-related cerebral activity in humans, J. Sleep Res. 2013

Schmidt C, Maire M, Reichert C F, Scheffler K, Klarhoefer M, Strobel W, Krebs J, Berthomier P, Berthomier C, Cajochen C. Circadian and homeostatic modulation of cognition-related cerebral activity in humans. J. Sleep Res. 21 (Suppl. 1), 1-371, 2012.

Brain mechanisms involved in the maintenance of wakefulness and associated cognitive processes are affected by inter-individual differences in sleep-wake regulation. For instance, different time-of-day and sleep-wake related modulations in cognition-associated cerebral activity are chronotype and PERIOD3 genotype dependent. However, the respective contributions of circadian and homeostatic processes on neurobehavioral performance and their cerebral correlates throughout the 24-h cycle remain largely unexplored. In a current project, we further investigate the impact of these processes on the cerebral correlates underlying human cognition in a 40-h multiple nap (NP) and sleep deprivation (SD) protocol.

Results: In this ongoing study we have observed that the circadian and sleep-wake homeostatic modulation in subjective sleepiness and objective vigilance undergoes considerable inter-individual differences. Electrophysiological data report the classical slow wave sleep rebound or decrease observed during the recovery night after the SD and NP conditions respectively. A preliminary analysis of the fMRI data, comparing task-related BOLD activity while performing the psychomotor vigilance task during the biological night (3 h before scheduled wake up time) in the first 11 participants indicated that differential homeostatic sleep pressure levels (SD versus NP) exert an effect on task-related BOLD activity. Globally, cortical responses (e.g. inferior frontal, middle temporal, insula) are higher while performing intermediate reaction time levels on the PVT when sleep pressure is kept low by multiple naps. When looking at BOLD activity underlying optimal PVT performance, at the end of the biological night, the preliminary results indicate that hypothalamic responses as well as several cortical areas (e.g. bilateral insula) are more active under NP as compared to SD conditions. Whether the above mentioned inter-individual variations in neurobehavioral performance are paralleled by differences in cognition-related BOLD activity is currently being analysed.

Conclusion: Time of day and disproportional homeostatic sleep pressure affect neurobehavioral performance modulation, which is mirrored at the cerebral level. The existence of large inter-individual variability in the vulnerability to circadian and/or homeostatic related detrimental effects on neurobehavioral performance should be taken into account in future analyses.

Symposium SFRMS – Sleep and Neuro-Psychiatric Disorders

Van Beers P. et al., HRV Analysis during Sleep: Clinical Interest of a New Automatic Sleep Analysis, Sleep 2009

Van Beers, P., Berthomier, C., Prado, J., Berthomier, P., & Coste, O., HRV Analysis during Sleep: Clinical Interest of a New Automatic Sleep Analysis, SLEEP Vol. 32, pp. A374-A374, 2009.

23rd Annual Meeting of the Associated Professional Sleep Societies (SLEEP 2009)
June 06-11, 2009, Seattle, Washington, USA

Berthomier C. et al., Real-Time Automatic Measure of Drowsiness based on a Single EEG Channel, Journal of Sleep Research, 2008

Berthomier C, Muzet A, Berthomier P, Prado J, Mattout J, Real-Time Automatic Measure of Drowsiness based on a Single EEG Channel, Journal of Sleep Research, Vol 17/suppl.1,P434, 2008

19th Congress of the European Sleep Research Society (ESRS)
September 9-13, 2008, Glasgow, UK

Berthomier C. et al., Real-Time Automatic Wake/Sleep Scoring based on a Single EEG Channel, Sleep 2008

Berthomier C, Herman-Stoïca M, Berthomier P, Drouot X, Prado J, Mattout J, d’Ortho MP, Real-Time Automatic Wake/Sleep Scoring based on a Single EEG Channel, Sleep, Vol 31 (suppl.), A338, 2008

22nd Annual Meeting of the Associated Professional Sleep Societies, LLC (SLEEP 2008)
June 7-12, 2008, Baltimore, MD, USA

Berthomier C. et al., Wake-REM-NREM Automatic Classification based on a Single EEG Channel: Epoch by Epoch Comparison with Human Sleep Scoring in Patients, J. Sleep Res., 2006

Berthomier C, Drouot X, Herman-Stoïca M, Berthomier P, Prado J, Benoit O, Mattout J, d’Ortho MP, Wake-REM-NREM Automatic Classification based on a Single EEG Channel: Epoch by Epoch Comparison with Human Sleep Scoring in Patients, J. Sleep Res., Vol 15/suppl.1, P295, 2006

18th Congress of the European Sleep Research Society (ESRS)
September 12-16, 2006, Innsbruck, Austria

Berthomier C. et al., A Wake-REM-NREM Automatic Analysis Using a Single EEG Channel: Epoch by Epoch Comparison with Human Sleep Scoring in Healthy Subjects, Sleep Medicine 2005

Berthomier C, Drouot X, Herman-Stoïca M, Berthomier P, Prado J, Mattout J, d’Ortho MP, A Wake-REM-NREM Automatic Analysis Using a Single EEG Channel: Epoch by Epoch Comparison with Human Sleep Scoring in Healthy Subjects, Sleep Medicine, Vol. 6/Suppl.2 (2005), S194

First Congress of the World Association of Sleep Medicine (WASM)
15-18 October 2005, Berlin, Germany

Want to collaborate?

Physip S.A

6 rue Gobert – 75011 Paris
+33 (0)1 42 17 00 10
contact@physip.fr

Copyright 2024 Physip.