Background
Aseega Technology is an extension of the work initiated by
Odile Benoit and Jacques Prado (Le Roux 86, Bouard 86), who proposed a semi-automatic
approach for the analysis of all-night sleep, based on a single EEG channel.
At that time, this signal was recorded using a research prototype.
This semi-automatic method was routinely applied for 12 years
by Benoit et al. to more than 500 recordings, including hypnotic pharmacological
trials (Benoit 94, Daurat 96, 97). Their work successfully demonstrated that
scoring sleep from a single EEG channel is possible, although challenging.
This single channel method was used as a starting point for Christian Berthomier's PhD thesis in signal processing. His work, supervised by J. Prado in collaboration with Dr. O. Benoit, formed the basis of an automatic method to process sleep EEG recorded under laboratory conditions (Berthomier 99, 00).
Since 2001, the research and development work carried out by
the Physip Company, directed by C. Berthomier, has led to the ASEEGA software.
ASEEGA provides a fully automatic analysis of the EEG signal delivered by recording
devices routinely used in sleep centers. The clinical validation of ASEEGA
was successfully performed on 15 healthy subjects in 2005 and on 15 patients
in 2006 (Berthomier 06, 07). The latest developments achieved real time scoring
(Berthomier 08).
Aseega is now being used in sleep linked research domains (Schmidt 09, Van Beers 09, Schmidt 10, Sterpenich 10).
Benoit O, Bouard G, Payan C, Borderies P and Prado J, Effect of a single dose (10 mg) of zolpidem on visual and spectral analysis of sleep of poor young sleepers, Psychopharmacology, 116:297-303, 1994.
Berthomier C, Prado J and Benoit O, Automatic sleep EEG analysis using filter banks, in Biomedical Sciences Instrumentation, 35():241-6, 1999.
Berthomier C, Prado J et Benoit O, Analyse Monovoie de l'Electroencéphalogramme de Sommeil. Méthode Adaptative, ITBM RBM, 21:143-9, 2000.
Berthomier C, Drouot X, Herman-Stoïca M, Berthomier P, Prado J, Benoit O, Mattout J, d'Ortho M-P, Wake-REM-NREM Automatic Classification based on a Single EEG Channel: Epoch-by-Epoch Comparison with Human Sleep Scoring in Patients. Journal of Sleep Research, 15:P295, 2006.
Berthomier C, Drouot X, Herman-Stoïca M, Berthomier P, Prado J, Bokar-thiré D, Benoit O, Mattout J, d'Ortho M-P,
Automatic Analysis of Single-Channel Sleep EEG: Validation in Healthy Individuals. Sleep,
30(11):1587-95, 2007.
Berthomier C, Herman-Stoïca M, Berthomier P, Drouot X, Prado J, Mattout J, d'Ortho MP, Real-Time Automatic Wake/Sleep
Scoring based on a Single EEG Channel. Sleep, 31:A338, 2008.
Bouard G, Benoit O, Lacombe J. Real-time analysis and semi-automatic classification of sleep EEG signals using a microprocessor. Part II: Application to normal and disturbed sleep. In: Court L, Trocherie S, Doucet J, eds. Le traitement du signal en électrophysiologie expérimentale et clinique du système nerveux central. Candé, France: Presses Lefrancq, 531-44, 1986
Daurat A, Foret J, Touitou Y and Benoit O, Detrimental influence of moderate bright light exposure upon alertness, performance and mood in the early morning, Neurophysiol. Clin 26:8-14, 1996.
Daurat A, Aguirre A, Foret J and Benoit O, Disruption of sleep recovery after 36h of exposure to moderately bright light, Sleep, 20(5):352-8, 1997.
Le Roux J, Moreau N, Prado J. Real-time analysis and semi-automatic classification of sleep EEG signals using a microprocessor. Part I: Principles of analysis. In: Court L, Trocherie S, Doucet J, eds. Le traitement du signal en électrophysiologie expérimentale et clinique du système nerveux central. Candé, France: Presses Lefrancq, 521-30, 1986.
Schmidt C, Collette F, Leclercq Y, Sterpenich V, Vandewalle G, Berthomier P, Berthomier C, Philipps C, Tinguely G, Darsaud A, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Balteau E, Degueldre C, Luxen A, Maquet P, Cajochen C, Peigneux P.
Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area.
Science, 324 (5926):516-9, 2009.
Van Beers P, Berthomier C, Prado J, Berthomier P, Coste O.
HRV Analysis during Sleep: Clinical Interest of a New Automatic Sleep Analysis.
Sleep, 32:A374, 2009.
Schmidt C, Peigneux P, Leclercq Y, Sterpenich V, Van Dewalle G, Philips C, Tinguely G, Gais S, Schabus M, Desseilles M, Dang-Vu T, Salmon E, Balteau E, Luxen A, Cajochen C, Maquet P, Collette F.
Working memory load affects chronotype- and time-of-day dependent cerebral activity modulations.
Journal of Sleep Research, 19: P541,2010.
Sterpenich V, Schmidt C, Albouy G, Matarazzo L, Van Haudenhuyse A, Boveroux P, Vaessen N, Berthomier P, Berthomier C, Degueldre C, Leclercq Y, Balteau E, Collette F,Luxen A, Philips C, Maquet P.
Conditioned auditory cues delivered during phasic REM sleep enhance adult human brain plasticity.
Journal of Sleep Research, 19: O310,2010.